The San Francisco 49ers vs Los Angeles Rams Match Player Stats and the Los Angeles Rams, two NFC West rivals with a long and intense history, met multiple times during the 2025 NFL season. Their matchups produced memorable performances and key statistical battles that highlighted both teams’ strengths and weaknesses. In this detailed article, we’ll examine the key player stats from two notable 49ers vs Rams games in the 2025 NFL season — the Week 5 overtime thriller and the Week 10 high‑scoring showdown — and provide comprehensive analysis of how individual performances shaped both contests.
Week 5: 49ers 26, Rams 23 (Overtime)
One of the most exciting games of the season between these rivals occurred early in October 2025. The 49ers secured a 26‑23 overtime win on the road in a hard‑fought divisional battle. This game was notable for strong individual efforts despite several key injuries on the San Francisco side.
Quarterbacks
Mac Jones (49ers)
- Completions / Attempts: 33 / 49
- Passing Yards: 342
- Touchdowns: 2
- Interceptions: 0
- Passer Rating: 100.9
Jones delivered a highly efficient performance while filling in as the starter, throwing for over 340 yards with two scores and no turnovers. This marked his sixth career 300‑yard game and showed his ability to lead a dynamic passing attack against a strong Rams defense.
Matthew Stafford (Rams)
- Completions / Attempts: 30 / 47
- Passing Yards: 389
- Touchdowns: 3
- Interceptions: 0
- Passer Rating: 111
Stafford was equally impressive, nearly leading the Rams to a comeback with almost 400 passing yards and three touchdowns. His accuracy and leadership kept the Rams competitive throughout regulation.
Rushing Leaders
Christian McCaffrey (49ers)
- Carries: 22
- Rushing Yards: 57
While bit limited on the ground, McCaffrey’s impact remained significant in keeping drives alive and contributing in the passing game as a safety valve.
Kyren Williams (Rams)
- Carries: 14
- Rushing Yards: 65
Williams was the Rams’ most effective runner, producing positive yardage and moving the chains at critical moments..
Receiving Leaders
Kendrick Bourne (49ers)
- Receptions: 10
- Receiving Yards: 142
Bourne was a focal point of San Francisco’s aerial attack, hauling in ten catches for a team‑high 142 yards.
Puka Nacua (Rams)
- Receptions: 10
- Receiving Yards: 85
- Touchdowns: 1
Nacua was Stafford’s primary receiving threat, contributing the Rams’ lone passing touchdown in regulation and consistently moving the chains.
Week 10: Rams 42, 49ers 26
Later in the season during Week 10, the Rams hosted the 49ers and dominated with a 42‑26 victory. This matchup showcased the Rams’ offensive firepower and ability to strike balance between aerial and ground attacks.
Quarterback Performances
Matthew Stafford (Rams)
- Passing Yards: 280
- Passing Touchdowns: 4
- Interceptions: 0
- Passer Rating: 127.1
Stafford’s performance was nothing short of elite, throwing four touchdown passes with no interceptions, significantly contributing to the Rams’ victory and enhancing his MVP candidacy. He became the first QB in NFL history to record four touchdowns and no interceptions in three straight games with this outing.
Mac Jones (49ers)
- Passing Yards: 319
- Passing Touchdowns: 3
- Interceptions: 1
Jones had a solid statistical night despite the loss, throwing for over 300 yards and three touchdown passes. However, the 49ers defense couldn’t contain the Rams’ offense consistently.
Rushing Attack
Kyren Williams (Rams)
Williams continued to be an explosive runner in this game, finding the end zone on multiple occasions and grinding out yardage that helped keep drives alive and control the tempo of the game.
49ers Rushing Leaders
The 49ers were less effective running the ball in this game, with few standout performances on the ground. Their effort to balance the attack was overshadowed by a more potent Rams offense.
Receiving Highlights
Rams Receiving Leaders
Several Rams receivers scored or made key plays, helping to stretch the field and keep the chains moving. Nacua and rookie targets significantly contributed to Stafford’s four‑touchdown performance.
49ers Receiving Leaders
George Kittle, Jauan Jennings, and Luke Farrell each had moments of success, with Jennings scoring a touchdown and Kittle hauling in key receptions that kept the 49ers within striking distance at times.
Key Defensive Plays
Across both games, defensive units on both sides made impact plays, even if they weren’t always highlighted on the main stat sheets. For example, Bryce Huff recorded pressures and sacks against the Rams, and Alfred Collins forced and recovered a fumble for the 49ers in Week 5, helping swing momentum at critical intervals.
Special teams also played a role, such as Eddy Piñeiro’s long field goals for the 49ers in early matchups, including a franchise‑long 59‑yard kick that provided important points.
Season Context and Impact
Overall, the 2025 head‑to‑head matchups between the 49ers and Rams reflected the balanced competition in the NFC West. The 49ers’ Week 5 overtime win showcased resilience and clutch play after injuries sidelined several starters, while the Rams’ Week 10 win highlighted their offensive depth and efficiency, particularly through Stafford’s MVP‑caliber performance.
The Rams’ offensive execution later in the season helped them secure victories and playoff positioning, while the 49ers continued to lean on Mac Jones and their varied offensive weapons to stay competitive. Individual statistics from these games reveal how vital quarterback play, efficient rushing, and reliable receiving can determine outcomes in closely matched division rivalries.
Conclusion
The 2025 battles between the San Francisco 49ers and Los Angeles Rams produced dynamic individual performances and unforgettable statistical showdowns. From Mac Jones’ passing masterclass in overtime to Matthew Stafford’s historic four‑touchdown night, these games offered fans a blend of strategy, skill, and resilience.
Despite injuries and shifting momentum, both teams demonstrated why their rivalry remains one of the most compelling in the NFL. Quarterbacks from both sides delivered standout performances, running backs grinded yardage, and receivers made critical plays that swung the games. This statistical breakdown not only highlights individual excellence but also illustrates how football success is built on teamwork, adaptability, and execution under pressure.
FAQs
Q: Who led the passing yards in the 49ers vs Rams games in 2025?
A: In the Week 5 overtime game, Matthew Stafford and Mac Jones both threw for over 300 yards; Stafford had roughly 389 and Jones had 342. In Week 10, Jones had 319 while Stafford finished with 280.
Q: Which players scored the most touchdowns in these matchups?
A: Matthew Stafford threw four touchdowns in Week 10, while in Week 5 both Stafford and Jones combined for five total passing touchdowns between them.
Q: How did the 49ers running game perform?
A: Christian McCaffrey and others provided solid efforts, but the 49ers generally struggled to dominate on the ground relative to the Rams’ balanced offense.
Q: Did injuries affect these games?
A: Yes — in the Week 5 game, the 49ers were missing several starters, making the overtime win even more impressive.
Q: What was a standout defensive moment?
A: Defensive plays like Alfred Collins’ forced fumble and Bryce Huff’s pressures were key in changing momentum in close sequences.
